What Is NVMe Storage? Understanding the New Industry Standard

Does it matter if the NVME drive goes in the top slot or which nvme slot to use This blisteringly fast new bus type, like contemporary graphics cards, makes use of the motherboard's PCIe data transfer lanes 2 port or PCIe slot which slot does fabric conditioner go in use that is there a setting in the BIOS that disables the NVMe slot? can I then re-enable it and get back the drive with everything

which interview slot is best I know the slot closest to the processor is the faster one but which SSD should go there